Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes
نویسندگان
چکیده
منابع مشابه
Epidemiology of Latency and Relapse in Plasmodium vivax Malaria
2015 ii Declaration I hereby declare that this thesis is my original work and it has been written by me in its entirety. I have duly acknowledged all the sources of information that have been used in this thesis. This thesis has also not been submitted for any degree in any university previously. iii When different fields of inquiry have been separately cultivated for a while, the borderland be...
متن کاملMolecular analysis of strains of Plasmodium vivax from paired primary and relapse infections.
Relapse infections are an important obstacle to the successful treatment and control of Plasmodium vivax malaria, but the molecular basis of relapse remains poorly understood. To provide insight into the molecular mechanisms of relapse, paired primary and relapse isolates of P. vivax were subjected to single-strand conformational polymorphism (SSCP) and sequence analysis of the circumsporozoite...
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Plasmodium vivax resistance to chloroquine (CQ) is currently reported in almost all countries where P. vivax is endemic. In Vietnam, despite a first report on P. vivax resistance to chloroquine published in the early 2000s, P. vivax was still considered sensitive to CQ. Between May 2009 and December 2011, a 2-year cohort study was conducted in central Vietnam to assess the recommended radical c...
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Plasmodium vivax causes debilitating but usually non-lethal malaria in most of Asia and South America. Prevention of relapse after otherwise effective therapy for the acute attack requires a standard daily dose of primaquine administered over 14 days. This regimen has < 90% efficacy in Thailand, and is widely regarded as ineffective because of poor compliance over the relatively long duration o...
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BACKGROUND Plasmodium vivax malaria is widespread, and the persistent liver stage causes relapse of the disease which contributes to continued P. vivax transmission. Primaquine is currently the only drug that cures the parasite liver stage, but requires 14 days to be effective and can cause haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In addition, there is some...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2017
ISSN: 1475-2875
DOI: 10.1186/s12936-017-1877-x